Local Inflammation Induces Complement Crosstalk Which Amplifies the Antimicrobial Response
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منابع مشابه
Local Inflammation Induces Complement Crosstalk Which Amplifies the Antimicrobial Response
By eliciting inflammatory responses, the human immunosurveillance system notably combats invading pathogens, during which acute phase proteins (CRP and cytokines) are elevated markedly. However, the Pseudomonas aeruginosa is a persistent opportunistic pathogen prevalent at the site of local inflammation, and its acquisition of multiple antibiotic-resistance factors poses grave challenges to pat...
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Striking commonalities in the roles of complement and antimicrobial peptides have recently been reported; their abilities to apply selection pressures on a bacterial population in the bloodstream (1), to contribute to enhanced phagocytosis of opsonized bacteria (2), and to interactively determine skin microbiome (3). Evolutionary roots for complement proteins and antimicrobial peptides are anci...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2009
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1000282